Post Doctoral Scientist | Columbia University | United States
Dr. Ayesha Zainab Beg is a Postdoctoral Research Scientist in the Department of Pediatrics at Columbia University Irving Medical Center (CUIMC), New York, where she investigates airway host–pathogen interactions with a focus on microbial pathogenesis and immunometabolism. She earned her Ph.D. in Biotechnology from Aligarh Muslim University, India, where her doctoral research elucidated the role of Pseudomonas aeruginosa biofilm components, particularly the functional amyloid Fap, in chronic airway infections and pathoadaptation, leading to seven peer-reviewed publications. She also holds an M.Sc. in Biotechnology and a B.Sc. (Hons.) in Biochemistry from the same institution. Dr. Beg’s current work explores how the cystic fibrosis airway environment drives adaptive genetic alterations in clinical isolates of P. aeruginosa and how airway immunometabolites regulate bacterial proteomes via post-translational modifications. Her research highlights include studies on Fap phosphorylation, multi-epitope vaccine design against functional amyloids, and the impact of bacterial metabolites on pulmonary infections, with recent publications in Journal of Biomolecular Structure and Dynamics, Nature Communications, and Microbiology Spectrum. She has presented her work at major conferences including ATS, Cold Spring Harbor Laboratory, and ECCMID, and has been recognized with multiple fellowships and awards, including the Young Achiever Award and Research Excellence Award. Her expertise spans molecular microbiology, proteomics, metabolomics, immunoinformatics, and murine models of infection, making her a leading early-career researcher at the interface of host–pathogen interactions and metabolic regulation. She has 153 citations from 10 documents with an h-index of 4.
Profiles: Google Scholar | Scopus | ORCID
Publications
1. Alam, P., Beg, A. Z., Siddiqi, M. K., Chaturvedi, S. K., Rajpoot, R. K., Ajmal, M. R., … (2017). Ascorbic acid inhibits human insulin aggregation and protects against amyloid-induced cytotoxicity. Archives of Biochemistry and Biophysics.
2. Beg, A. Z., Farhat, N., & Khan, A. U. (2021). Designing multi-epitope vaccine candidates against functional amyloids in Pseudomonas aeruginosa through immunoinformatic and structural bioinformatics approach. Infection, Genetics and Evolution.
3. Beg, A. Z., Rashid, F., Talat, A., Haseen, M. A., Raza, N., Akhtar, K., Dueholm, M. K. D., … (2023). Functional amyloids in Pseudomonas aeruginosa are essential for the proteome modulation that leads to pathoadaptation in pulmonary niches. Microbiology Spectrum.
4. Beg, A. Z., & Khan, A. U. (2018). Genome analyses of blaNDM-4 carrying ST 315 Escherichia coli isolate from sewage water of one of the Indian hospitals. Gut Pathogens.
5. Beg, A. Z., & Khan, A. U. (2019). Exploring bacterial resistome and resistance dissemination: An approach of whole genome sequencing. Future Medicinal Chemistry.