Dr. Leticia Peris is a distinguished neuroscientist and cell biologist whose research focuses on uncovering the molecular mechanisms that regulate the neuronal cytoskeleton and its dysfunction in neurodegenerative diseases. She serves as an Inserm Research Scientist at the Grenoble Institute of Neurosciences (UGA–INSERM U1216, France), where her work has significantly advanced the understanding of tubulin post-translational modifications and their role in neuronal morphogenesis, synaptic integrity, and neurodegeneration. Dr. Peris made pioneering contributions by identifying the tubulin carboxypeptidases VASH1/2–SVBP complex and elucidating their importance in neuronal organization and neurodevelopmental disorders. Her research further demonstrated how dysregulated tubulin modifications contribute to synaptic degeneration in Alzheimer’s disease and revealed new mechanisms of L-Dopa–induced synaptotoxicity in Parkinson’s disease. With an extensive record of publications in high-impact journals, international collaborations, and innovative patents, her work bridges fundamental neuroscience and translational medicine. She actively collaborates with leading researchers across France, Argentina, Germany, and the United States, including teams at Columbia University, Boston Children’s Hospital, and Humboldt University. A member of several international scientific societies and editorial boards, Dr. Peris is also deeply engaged in ethical and ecological initiatives promoting responsible and sustainable scientific practices. Her ongoing projects aim to rejuvenate neuronal cytoskeleton function as a therapeutic strategy against neurodegeneration, making her a leading voice in cellular neurobiology and a key contributor to the global fight against Alzheimer’s and Parkinson’s diseases. She has 2741 citations from 36 documents with an h-index of 24.
Profiles: Scopus | ORCID
Publications
1. Zorgniotti, A., Sharma, A., Ramirez-Rios, S., Sanyal, C., Aleman, M., Ditamo, Y., Moutin, M. J., Bisig, C. G., & Peris, L. (2024). L-Dopa incorporation into tubulin alters microtubule dynamics and reduces dendritic spine invasion and synapse maintenance [Preprint].
2. Konietzny, A., Han, Y., Popp, Y., van Bommel, B., Sharma, A., Delagrange, P., Arbez, N., Moutin, M. J., Peris, L., & Mikhaylova, M. (2024). Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination. Journal of Cell Science.
3. Konietzny, A., Peris, L., Han, Y., Popp, Y., van Bommel, B., Sharma, A., Delagrange, P., Arbez, N., Moutin, M. J., & Mikhaylova, M. (2023). Efficient axonal trafficking of endolysosomes depends on the balanced ratio of microtubule tyrosination and detyrosination [Preprint].
4. Peris, L. (2022). Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease. Frontiers in Cell and Developmental Biology.
5. Peris, L. (2022). Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer’s disease. Brain: A Journal of Neurology.
Dr. Leticia Peris’s research advances global neuroscience by uncovering cellular mechanisms that drive neurodegenerative diseases, paving the way for innovative therapeutic strategies. Her work bridges fundamental biology and translational medicine, contributing to improved brain health and societal well-being worldwide.